At the beginning of the season, the Buffalo Bills and Pittsburgh Steelers were among the most popular picks to make the 2025 NFL Playoffs, according to NFL future market odds.
Pittsburgh has been fighting to stay relevant with head coach Mike Tomlin, who many fans believe is no longer effective.
Since Ben Roethlisberger's retirement, the Steelers have struggled to stay above .500.
In turn, fans are increasingly annoyed with Tomlin, who has not led a team to the Super Bowl in 15 years.
Meanwhile, the Bills are fighting for an AFC wild card spot. Buffalo has been good enough but not dominant.
With two iconic brands that enjoy large followings clashing, betting activity will be intense.
Last week, Pittsburgh quarterback Aaron Rodgers was out with a left wrist injury. However, head coach Mike Tomlin expects him to play against the Bills.
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Buffalo Bills at Pittsburgh Steelers Odds at Bookmaker
Acrisure Stadium is the venue for the matchup between the Buffalo Bills and the Pittsburgh Steelers on Sunday, November 30, 2025. Kickoff time is at 4:25 p.m. ET with television coverage on CBS.
Oddsmakers opened with Buffalo as a 4.5-point favorite and Pittsburgh as a 4.5-point dog.
Buffalo is a -225 moneyline favorite with Pittsburgh as a +188 moneyline dog.
Buffalo and Pittsburgh opened with a total of 47.5.
Buffalo Bills
In the last game, the Buffalo Bills lost 23-19 to the Houston Texans as 5.5-point road dogs. The game went under the total of 44.5.
Buffalo is 7-4 straight up, 5-6 against the spread, and 5-6 over/under the total.
Buffalo ranks 3rd for total offense, 10th for passing, 1st for rushing, 5th for scoring, and 26th for fewest turnovers committed.
Buffalo ranks 12th for total defense, 1st vs. the pass, 30th vs. the rush, 16th for fewest points allowed, and 19th for takeaways.
Buffalo has covered one out of its most recent three games.
Buffalo went under the total in three of its last four matchups.
Pittsburgh Steelers
Last game, the Pittsburgh Steelers lost 31-28 against the Chicago Bears as 2.5-point road dogs. The game went over the total of 47.
Pittsburgh is 6-5 straight up, 5-6 against the spread, and 6-5 over/under the total.
Overall, Pittsburgh ranks 28th for total offense, 23rd for passing, 26th for rushing, 11th for scoring, and 11th for fewest turnovers committed.
Pittsburgh ranks 28th for total defense, 31st vs. the pass, 14th vs. the rush, 20th for fewest points allowed, and 14th for takeaways.
Pittsburgh covered one out of its three most recent games.
Pittsburgh went under the total in three of its last four matchups.
Bills at Steelers Betting Trends
The Bills failed to cover five of their most recent eight away games. Buffalo went under the total in three of their last four away games.
Pittsburgh covered the spread in 11 of its last 15 home games. The Steelers went under the total in 7 of their last 10 home games.
In the series between the Steelers and Bills, Buffalo covered the spread in four of the most recent five meetings. The Steelers and Bills went under the total in four of those five games.
Specifically in Pittsburgh, the Steelers have bossed the payout window. Pittsburgh came away with the cash in six of its last seven home games. Seven of the last eight games between the Bills and Steelers in Pittsburgh went under the total.
Bills at Steelers Best Bets
Buffalo and Pittsburgh are popular brands with gamblers as perennial playoff contenders.
Sharps like Buffalo in this spot as a quality team.
Squares love the Steelers at home in a big game in the late afternoon CBS window.
In this situation, Buffalo offers more value as the quality road team in an even NFL betting matchup, given Pittsburgh’s unstable QB situation.
This game should be tight and stay under the total.
Main Pick: Buffalo Bills
Over/Under Pick: Under the Total
Player Prop Picks: Josh Allen Over the Passing Yards Total
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