The San Francisco 49ers knocked off the defending Super Bowl champion Philadelphia Eagles for an impressive playoff win.
The 49ers' reward is a date in Seattle against the Seahawks, the NFC’s top seed.
Seattle and San Francisco have one of the most brutal rivalries in pro football and face the threat of playoff extinction.
The Buffalo Bills showed their veteran playoff savviness in an impressive road win over the Jacksonville Jaguars.
Buffalo now faces the Denver Broncos, the top seed in the AFC, in a divisional playoff game in the Mile High City.
Saturday’s NFL Divisional Playoffs doubleheader has it all. Betting traffic opened with a stamped as interest is as high as ever.
Get the latest NFL Divisional Round news, check out the current betting lines for the games, and don’t miss the football action, all with the best odds at BookMaker!
Buffalo Bills at Denver Broncos Odds at Bookmaker
Empower Field at Mile High in Denver, CO, hosts the AFC Divisional Playoff matchup between the Buffalo Bills and the Denver Broncos on Saturday, January 17, 2026. Kickoff time is at 4:30 p.m. ET with television coverage on CBS.
Oddsmakers opened with Buffalo as a 1.5-point favorite and Denver as a 1.5-point dog.
Buffalo and Denver are each priced at -108 on the moneyline.
Buffalo and Denver opened with a total of 46.5.
San Francisco 49ers at Seattle Seahawks Odds at Bookmaker
Lumen Field in Seattle, WA, will host the NFC Divisional playoff game between the San Francisco 49ers and Seattle Seahawks on Saturday, January 17, 2026. Kickoff time is at 8 p.m. ET with television coverage on FOX.
Oddsmakers opened with Seattle as a 7-point favorite and San Francisco as a 7-point dog.
Seattle is a -360 moneyline favorite with San Francisco as a +290 moneyline dog.
San Francisco and Seattle opened with a total of 45.5.
Buffalo Bills
Last game, the Buffalo Bills won 27-24 against the Jacksonville Jaguars as 2.5-point road favorites. The game went under the total of 51.5.
In the regular season, Buffalo was 12-5 straight up, 8-9 against the spread, and 9-8 over/under the total.
Buffalo has covered two out of its most recent two games. Buffalo went over the total in one of its last three matchups.
Buffalo ranks 4th for total offense, 15th for passing, 1st for rushing, 5th for scoring, and 16th for fewest turnovers committed.
Buffalo ranks 7th in total defense, 1st vs. the pass, 28th vs. the rush, 12th in fewest points allowed, and 14th in takeaways.
Denver Broncos
Last week, the Broncos were on a bye as the top seed in the AFC.
In the regular season, Denver was 14-3 straight up, 7-9-1 against the spread, and 7-10 over/under the total.
Denver ranks 10th in total offense, 11th in passing, 16th in rushing, 14th in scoring, and 12th in fewest turnovers committed.
Denver ranks 2nd for total defense, 7th vs. the pass, 2nd vs. the rush, 3rd for fewest points allowed, and 21st for takeaways.
Denver has covered two out of its most recent six games. Denver went under the total in its two most recent matchups.
San Francisco 49ers
Last game, the San Francisco 49ers won 23-19 against the Philadelphia Eagles as 5.5-point road dogs. The game went under the total of 44.5.
In the regular season, San Francisco was 12-5 straight up, 11-6 against the spread, and 10-6 over/under the total.
San Francisco has covered six out of its most recent eight games. The 49ers went over the total in one of their last three matchups.
San Francisco ranks 18th for total offense, 9th for passing, 26th for rushing, 10th for scoring, and 17th for fewest turnovers committed.
San Francisco ranks 14th in total defense, 17th vs. the pass, 5th vs. the rush, 13th in fewest points allowed, and 30th in takeaways.
Seattle Seahawks
Last week, the Seattle Seahawks were on a bye as the top seed in the NFC.
In the regular season, Seattle was 14-3 straight up, 12-5 against the spread, and 9-8 over/under the total.
Seattle has covered two out of its most recent two games. Seattle went under the total in three of its last four matchups.
Seattle ranks 8th for total offense, 8th for passing, 10th for rushing, 3rd for scoring, and 31st for fewest turnovers committed.
Seattle ranks 6th in total defense, 10th vs. the pass, 3rd vs. the rush, 1st in fewest points allowed, and 5th in takeaways.
Saturday Divisional Playoff Betting Trends
Buffalo covered the spread in eight of its last nine games against Denver, including four of their last five visits to Empower Field.
San Francisco covered four of its last five away games against Seattle.
Denver and Buffalo went under the total in four of their last six meetings.
San Francisco and Seattle went under the total in their last five meetings.
Saturday Divisional Playoff Best Bets
Denver is a live home dog and the AFC top seed.
San Francisco is a quality underdog getting a boatload of points.
Both games feature strong defenses and should be tough and tight.
Main Pick: Denver Broncos and San Francisco 49ers
Over/Under Pick: Both Games Under the Total
Player Prop Picks: Bo Nix and Sam Darnold Under the Passing Yards Totals
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