When Mac Jones arrived to be a backup QB with the San Francisco 49ers, nobody paid much attention. Originally, Jones was expected to be drafted by the 49ers in 2021. Instead, San Francisco took Trey Lance and ended up with Brock Purdy as the starter.
Because Lance was injured and Purdy became a Pro Bowl starter. But when Purdy was lost to injury, Jones shone as his replacement. Now the 49ers have a QB controversy.
Meanwhile, the Atlanta Falcons have given Michael Pennix Jr a shot as the starting QB over Kirk Cousins.
San Francisco is one of the most popular brands on the NFL board, while Atlanta is catching the attention of everyone for their surprisingly good start. Add in NBC Sunday Night Football and you have a strong wagering draw.
Explore the latest Week 7 NFL betting lines and predictions for Sunday Night Football.
NFL Betting Lines
Atlanta Falcons at San Francisco 49ers Odds at Bookmaker
Levi’s Stadium is the venue for the NFC matchup of the Atlanta Falcons vs. the San Francisco 49ers on Sunday, October 19, 2025. Kickoff is at 8:20 p.m. ET with coverage on NBC Sunday Night Football.
Oddsmakers opened with the Atlanta Falcons as a 3-point road dog. The San Francisco 49ers opened as a 3-point home favorite.
The Falcons opened as +148 moneyline dogs. The 49ers are -176 moneyline favorites.
The 49ers and Falcons opened with a total of 45.5.
Atlanta Falcons
Last game, the Atlanta Falcons beat the Buffalo Bills 23-14 as 4-point home dogs. The game went under the total of 50.
As a result of beating the Bills, the Falcons are 3-2 straight up and against the spread and 1-4 under the total.
Atlanta ranks 1st for total offense, 2nd for passing, 1st for rushing, 27th for scoring, and 10th for turnovers.
Defensively, the Falcons rank 13th overall, 4th vs. the pass, 29th vs. the rush, 16th for points allowed, and 8th for takeaways.
San Francisco 49ers
The San Francisco 49ers are coming off a 30-19 loss to the Tampa Bay Buccaneers as 3-point road dogs. The game went over the total of 47.5.
The 49ers have a record of 4-2 straight up, 3-3 against the spread, and 4-2 over the total.
San Francisco has NFL metrics of 6th for total offense, 1st for passing, 30th for rushing, 25th for scoring, and 28th for fewest turnovers committed.
The 49ers rank 16th for total defense, 16th vs. the pass, 14th vs. the rush, 14th for fewest points allowed, and 31st for takeaways.
Mac Jones tossed two interceptions with no TD passes against Tampa Bay and was sacked six times.
Brock Purdy has “a chance” to play against the Falcons (Check Status).
Falcons at 49ers Betting Trends
The Falcons covered only one of their most recent seven away games.
Five of their last seven away games went under the total.
San Francisco covered only four of its most recent 18 home games.
Five of the 49ers' last nine home games went under the total.
In the series between the 49ers and Falcons, Atlanta got the money in six of their last ten games against San Francisco.
Three of the last five games between the Falcons and 49ers went under the total.
Specifically in San Francisco, the Falcons got the cash in three of their most recent five visits.
Three of those five games went over the total.
Falcons at 49ers Best Bets
In this situation, the 49ers will be overpriced as the more popular brand.
As mentioned earlier, the 49ers have not been a reliable betting value at home.
As was previously noted, Atlanta has had the advantage in this series.
Main Pick: Atlanta Falcons
Over/Under Pick: Under the Total
Player Prop Picks: Michael Pennix Jr. Over the Total Yards Total
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