At the beginning of the season, there was speculation that the Kansas City Chiefs' dynasty could be in jeopardy.
Instead, the Denver Broncos and Los Angeles Chargers were touted as the main threats.
But one team that was ignored in the preseason future market could be the team that ultimately ends Kansas City’s reign.
The Indianapolis Colts are fighting for the top seed in the AFC.
Meanwhile, the Chiefs have been fighting to stay in the AFC wild card race.
On Sunday, Kansas City hosts Indianapolis with playoff implications on the line.
As one of the biggest games of the weekend between two power brands, betting activity will be significant.
Get the latest NFL Week 12 news, check out the current betting lines for the games, and don’t miss all with the best odds at BookMaker!
Indianapolis Colts at Kansas City Chiefs Odds at Bookmaker
GEHA Field at Arrowhead Stadium is the venue for the matchup between the Kansas City Chiefs and the Indianapolis Colts on Sunday, November 23, 2025. Kickoff time is at 1 p.m. ET with television coverage on CBS.
Oddsmakers opened with Kansas City as a 3.5-point favorite and Indianapolis as a 3.5-point dog.
Kansas City is a -190 moneyline favorite against Indianapolis, a +160 moneyline dog.
KC and Indy opened with a total of 49.5.
Indianapolis has taken gamblers by surprise in 2025. Hence, that has been one of the keys to their success on the NFL board.
Equally important was the acquisition of quarterback Daniel Jones from the New York Giants. Jones is a Comeback Player of the Year candidate.
Kansas City remains one of the most popular bands on the board.
Naturally, that popularity makes it hard for the Chiefs to get full value.
Especially when they play at Arrowhead, the Chiefs are among the most popular plays among casual bettors.
Indianapolis Colts
Last game, the Indianapolis Colts beat the Atlanta Falcons 31-25 in overtime as 6-point home favorites. The game went over the total of 49.5. As a result,Indianapolis is 8-2 straight up, 6-3-1 against the spread, and 6-4 over/under the total.
Indianapolis ranks 3rd for total offense, 5th for passing, 4th for rushing, 1st for scoring, and 15th for fewest turnovers committed.
Indianapolis ranks 17th in total defense, 24th vs. the pass, 5th vs. the rush, 9th in fewest points allowed, and 5th in takeaways.
Late on, Indianapolis has covered two out of its most recent five games. Indianapolis went over the total in four of its last five matchups.
Indianapolis is in 1st place in the AFC South Division.
Kansas City Chiefs
Last game, the Kansas City Chiefs lost 22-19 to the Denver Broncos as 4.5-point road favorites. The game went under the total of 45.
Kansas City is 5-5 straight up, 5-5 against the spread, and 3-7 over/under the total.
Kansas City ranks 8th for total offense, 6th for passing, 18th for rushing, 9th for scoring, and 3rd for fewest turnovers committed.
Kansas City ranks 7th for total defense, 11th vs. the pass, 8th vs. rush, 4th for fewest points allowed, and 21st for takeaways.
Kansas City failed to cover its most recent two games. Kansas City went under the total in five of its last five matchups.
Kansas City is in 3rd place in the AFC West Division.
Colts at Chiefs Betting Trends
Indianapolis has covered only two of its last seven road games.
The Colts went under the total in only two of their last eight games.
Despite its problems, the Chiefs have dominated the betting window at Arrowhead this year.
Kansas City got the money in four of its most recent five games.
Consider that the Chiefs beat the Lions and Ravens at home earlier this year.
The Chiefs went under the total in four of their last five home games.
In the series between the Colts and Chiefs, Indianapolis has bossed the cashier’s cage with 14 payouts in the most recent 19 meetings.
Nine of the last 11 meetings between the Chiefs and Colts went under the total.
Specifically at Arrowhead, the Colts covered the spread in eight of their most recent 10 visits against the Chiefs.
The last four meetings between the Colts and Chiefs at Kansas City went under the total.
Colts at Chiefs Best Bets
As mentioned earlier, the Chiefs have risen to the occasion several times at Arrowhead in 2025.
Indianapolis failed to cover in its last two games and could be cooling off.
Also, the Colts could be rusty coming off a bye week.
Look for Kansas City to burn the boats and cover with the win.
Main Pick: Kansas City Chiefs
Over/Under Pick: Under the Total
Player Prop Picks: Daniel Jones Under the Passing Yards Total
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