San Francisco 49ers head coach Kyle Shanahan proved once and for all why he is one of the best in the NFL.
Shanahan had to navigate a potential quarterback controversy when starter Brock Purdy missed large chunks of time, and his backup, Mac Jones, performed well in his absence.
But Shanahan held firm, making it clear that Purdy would remain atop the depth chart when he healed.
Purdy rewarded Shanahan’s confidence with an outstanding performance that has the 49ers in a prime playoff position with a shot at the top NFC seed.
On Saturday night, the 49ers will host the Seahawks in one of the biggest games of the 2025-26 season. The winner will earn the top seed in the NFC with a first-round bye and home-field advantage for every playoff game.
Gambling interest and activity will be over the top for this high-stakes matchup.
The fact that this game is on ABC and ESPN prime time will add eyeballs and betting traffic.
Get the latest NFL Week 18 news, check out the current betting lines for the games, and don’t miss the football action, all with the best odds at BookMaker!
Seattle Seahawks at San Francisco 49ers Odds at Bookmaker
Levi’s Stadium in Santa Clara, CA, is the venue for the matchup between the San Francisco 49ers and Seattle Seahawks on Saturday, January 3, 2026. Kickoff time is at 8 p.m. ET with television coverage on ABC and ESPN.
Oddsmakers opened with San Francisco as a 1.5-point favorite and Seattle as a 1.5-point dog.
San Francisco and Seattle opened at -108 choices on the moneyline.
The 49ers and Seahawks opened with a total of 49.5.
The 49ers will be a logical and popular pick as a legacy franchise with a notorious home field advantage.
The Seahawks will get their share of support as one of the most fundamentally sound teams in the NFL.
The price is right for this game and shows an even split in betting action on both sides.
Square money isn't affecting prices, keeping the line honest.
Seattle Seahawks
Last game, Seattle won 27-10 against the Carolina Panthers as 6.5-point road favorites. The game went over the total of 43.
Seattle is 13-3 straight up, 11-5 against the spread, and 9-7 over/under the total.
Seattle has covered three out of its most recent five games. Seattle went under the total in two of its last three matchups.
Seattle ranks 10th for total offense, 10th for passing, 17th for rushing, 2nd for scoring, and 31st for fewest turnovers committed.
Seattle ranks 4th in total defense, 10th vs. the pass, 2nd vs. the rush, 2nd in fewest points allowed, and 5th in takeaways.
San Francisco 49ers
Last game, San Francisco won 42-38 against the Chicago Bears as 4.5-point home favorites. The game went over the total of 51.5.
San Francisco is 12-4 straight up, 10-6 against the spread, and 10-5 over/under the total.
San Francisco has covered five out of its most recent six games. San Francisco went over the total in three of its last three matchups.
San Francisco ranks 8th for total offense, 4th for passing, 23rd for rushing, 8th for scoring, and 23rd for fewest turnovers committed.
San Francisco ranks 19th for total defense, 25th vs. the pass, 6th vs. the rush, 13th for fewest points allowed, and 30th for takeaways.
Seahawks at 49ers Betting Trends
San Francisco has covered six consecutive games.
The 49ers went over the total in six of their most recent eight games.
The 49ers covered four of their last five games at home.
Seattle covered 11 of their most recent 15 games.
San Francisco covered the spread in six of their last eight meetings with the Seahawks.
San Francisco beat Seattle straight up in seven of the last eight meetings.
Four of the last five meetings between the Seahawks and 49ers in San Francisco went under the total.
Seahawks at 49ers Best Bets
In this situation, the 49ers have a definite advantage with their home field.
This game should be a defensive struggle between two of the most solid and balanced teams in the NFL.
Main Pick: San Francisco 49ers
Over/Under Pick: Under the Total
Player Prop Picks: Sam Darnold Under the Passing Yards and TD Passes Totals
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