First and foremost, gamblers must know that UFC 321 starts at 2 p.m. Eastern Time in the United States! The event takes place in the United Arab Emirates.
Saturday Night from the United Arab Emirates, UFC wagering action will offer a main card for the ages. Specifically, there are two championship bouts.
Additionally, all five main card bouts are ranked matchups. The main event is the heavyweight championship fight between defending champion Tom Aspinall and #1-ranked Ciryl Gane.
Furthermore, #1-ranked Virna Jandiroba and #5-ranked Mackenzie Dern will fight for the women’s strawweight title.
Also catching attention is the bantamweight bout between #2-ranked Umar Nurmagomedov and #8-Mario Bautista.
And then #2-ranked Alexander Volkov will face #5 Jailton Almeida in a heavyweight matchup.
With the heavyweight title on the line, betting interest for UFC 321 will be over the top. The card is loaded with strong competition and excellent betting value opportunities.
MMA Betting Lines
UFC 321: Aspinall vs. Gane Betting at Bookmaker
On Saturday, October 25, 2025, UFC 321 will take place at the Etihad Arena, Yas Island, Yas West, United Arab Emirates. Main card action begins at 2 p.m. ET with television coverage on ESPN+.
UFC 321 Main Card Matchups and Odds
Heavyweight Bout
C-Tom Aspinall -400 vs. #1-Ciryl Gane +300
Tom Aspinall has a career record of 15-3. In comparison, Ciryl Gane stands at 13-2 for his career.
On November 11, 2023, Tom Aspinall defeated Sergei Pavlovich in a 1st-round knockout for the interim UFC heavyweight championship in New York.
Subsequently, Aspinall won a 1st-round knockout against Curtis Blaydes on July 27, 2024, in Manchester, England. Aspinall retained his interim UFC heavyweight title.
Previously, on July 22, 2023, Aspinall won a 1st-round TKO against Marcin Tybura in London.
It was an impressive comeback for Aspinall, who was coming off a 1st-round knockout loss to Curtis Blaydes on July 23, 2022, in London. The loss to Blaydes snapped an 8-bout winning streak.
Ciryl Gane is a former interim UFC heavyweight champion. Although he lost two of his most recent five bouts, he won his last two matchups.
Gane is coming off a split decision win over Alexander Volkov on December 7, 2024, in Las Vegas.
Previously, Gane won a 2nd-round TKO over Serghei Spivac on September 2, 2023, in Paris.
On March 4, 2023, Gane lost a 1st-round submission to Jon Jones for the vacant UFC heavyweight championship.
On September 3, 2022, Gane won a 3rd-round knockout against Tai Tuivasa in Paris.
Initially, on August 7, 2021, Gane won a unanimous decision against Derrick Lewis in Houston, TX, for the interim UFC heavyweight title.
However, on January 22, 2022, Game lost a unanimous decision to Francis Ngannou in Anaheim, CA. That bout was for the UFC heavyweight championship.
Women’s Strawweight Title Bout
#1 Virna Jandiroba EVEN vs. #5-Mackenzie Dern -120
Overall, Virna Jandiroba has a career record of 22-3. Mackenzie Dern stands at 15-5 for her career.
Virna Jandiroba is riding a 5-bout winning streak. She is coming off a unanimous decision loss to Yan Xiaonan on April 12, 2025, in Miami.
Previously, on July 20, 2024, Jandiroba won a 2nd-round submission to Amanda Lemos in Las Vegas.
On March 30, 2024, Jandiroba won a unanimous decision against Loopy Godinez in Atlanta City.
MacKenzie Dern is coming off two consecutive wins that followed two consecutive losses.
Overall, Dern is 4-4 in her most recent eight bouts.
Bantamweight Bout
#2 Umar Nurmagomedov -500 vs. #8 Mario Bautista +350
Umar Nurmagomedov has a career record of 18-1 with the UFC betting odds. In turn, Bautista has a career record of 16-2.
Last time out, Umar Nurmagomedov lost a unanimous decision to Merab Dvalishvili on January 18, 2025. That loss snapped an 18-bout winning streak for Nurmagomedov.
Mario Bautista is riding an 8-bout winning streak.
Heavyweight Bout
#2 Alexander Volkov +140 vs. #5 Jailton Almeida -170
Alexander Volkov has a career record of 38-11. Jailton Almedia stands at 22-3 for his career.
Light Heavyweight Bout
#7 Aleksandar Rakic -105 vs. Azamat Murzakanov -115
Aleksandar Rakic has a career record of 14-5. Azamat Murzakanov is 15-0 for his career.
UFC 321: Aspinall vs. Gane Best Bets
Specifically, in the main event between Tom Aspinall and Ciryl Gane, Aspinall is in much better recent form.
While the price is higher than desired, Gane has not shown the consistency needed to take a chance on him.
UFC 321 Main Pick: Tom Aspinall
UFC 321 Fighter Prop Pick: Tom Aspinall to Win by Decision
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