At the beginning of the season, the Buffalo Bills and Philadelphia Eagles were in the upper tier of Super Bowl favorites.
Of course, Philadelphia would be a favorite as the defending Super Bowl champion.
Similarly, the Bills have been in the Super Sunday conversation for the past decade.
However, both clubs have had to weather storm clouds this season. Philadelphia players have clashed with quarterback Jalen Hurts.
Meanwhile, the Bills have had to bout moments of inconsistency and the surprise emergence of the New England Patriots.
The Eagles and Bills will be one of the top betting draws of the weekend, if not the season. Especially on a holiday weekend, both brands are powerful with enhanced appeal.
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Philadelphia Eagles at Buffalo Bills Odds at Bookmaker
Highmark Stadium in Orchard Park, NY, is the venue for the matchup between the Philadelphia Eagles and the Buffalo Bills on Sunday, December 28, 2025. Kickoff time is at 4:25 p.m. ET with television coverage on FOX.
Buffalo opened as a 2.5-point favorite with Philadelphia as a 2.5-point dog.
Buffalo is a -134 moneyline chalk with Philadelphia at +114.
The Bills and Eagles opened with an o/u total of 45.5.
Betting action will split evenly between Wise Guys and the Casual sector for this even matchup.
Philadelphia Eagles
Last game, the Philadelphia Eagles won 29-18 against the Washington Commanders as 7 7-point road favorites. The game went over the total of 43.5.
Philadelphia is 10-5 straight up, 9-6 against the spread, and 6-9 over/under the total.
Overall, Philadelphia ranks 22nd for total offense, 24th for passing, 16th for rushing, 16th for scoring, and 8th for fewest turnovers committed.
Philadelphia ranks 12th for total defense, 7th vs. the pass, 21st vs. the rush, 3rd for fewest points allowed, and 15th for takeaways.
Philadelphia has covered two out of its most recent two games. Philadelphia went under the total in six of its last seven matchups.
Buffalo Bills
Last game, the Buffalo Bills won 23-20 against the Cleveland Browns as 10.5-point road favorites. The game went over the total of 41.5.
Buffalo is 11-4 straight up, 7-8 against the spread, and 8-7 over/under the total.
Buffalo ranks 4th for total offense, 18th for passing, 1st for rushing, 4th for scoring, and 18th for fewest turnovers committed.
Buffalo ranks 11th for total defense, 2nd vs. the pass, 29th vs. the rush, 16th for fewest points allowed, and 9th for takeaways.
Buffalo has covered one out of its most recent three games. Buffalo went over the total in three of its last three matchups.
Eagles at Bills Betting Trends
The Eagles have been a highly profitable road value.
Philadelphia covered the spread in nine of its most recent 13 away games. The Eagles went under the total in four of their last seven road tilts.
The Bills have been in the black at home.
Buffalo covered the spread in six of its most recent ten home games. The Bills went over the total in six of their last eight home tilts.
In the series between the Eagles and Bills, Philadelphia covered the spread in the most recent three meetings. The Bills and Eagles went over the total in three of their last four showdowns.
Specifically at Buffalo, the Eagles got the money in two of their last three visits. The last two games between the Eagles and Bills at Buffalo went over the total.
Eagles at Bills Best Bets
As is almost always the case, the casual sector like the power brands at home.
On the other hand, Wise Guys love a power road club on the road with consistently better odds.
In this situation, Philadelphia is getting the more favorable price as the power road team.
Meanwhile, Buffalo has not been an effective value against the Eagles.
Indeed, Philadelphia is a sharp type of play.
Main Pick: Philadelphia Eagles
Over/Under Pick: Under the Total
Player Prop Picks: Jalen Hurts Over the Total Yards Total
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