The Buffalo Bills and Kansas City Chiefs have an ancient rivalry that dates back to the founding of the American Football League in 1960. They even played in the 1966 AFL Championship Game for the right to play in Super Bowl I.
Since 2021, the rivalry has reached a new peak. The Bills and Chiefs have met in the playoffs four times, with Kansas City winning and covering each time.
Thus, Buffalo and the Bills Mafia hate the Chiefs with extra venom. On Sunday, the two powers will clash again for seeding and bragging rights.
The Chiefs-Bills rivalry drives a massive betting handle, as both teams have plenty at stake. Fans and gamblers find this classic, hated matchup irresistible for both viewing and wagering.
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Kansas City Chiefs at Buffalo Bills Odds at Bookmaker
Highmark Stadium in Orchard Park, NY, will host the Buffalo Bills vs. Kansas City Chiefs matchup on Sunday, November 2, 2025. The kickoff time is at 4:25 p.m. ET, with television coverage on CBS.
Oddsmakers opened with Kansas City as a 1.5-point favorite and Buffalo as a 1.5-point dog.
Kansas City is a -120 moneyline favorite with Buffalo as a +100 moneyline dog.
Kansas City and Buffalo opened with a total of 52.5.
Kansas City Chiefs
Last game, the Kansas City Chiefs won 28-7 against the Washington Commanders as 10-point home favorites. The game went under the total of 48.
Kansas City is 5-3 straight up, 5-3 against the spread, and 3-5 over/under the total.
Kansas City ranks 2nd for total offense, 2nd for passing, 4th for rushing, 8th for scoring, and 4th for fewest turnovers committed.
Kansas City ranks 12th for total defense, 11th vs. the pass, 18th vs rush, 3rd for fewest points allowed, and 14th for takeaways.
Buffalo Bills
Last game, the Buffalo Bills won 40-9 against the Carolina Panthers as 7.5-point road favorites. The game went over the total of 48.5.
Buffalo is 5-2 straight up, 3-4 against the spread, and 4-3 over/under the total.
Overall, Buffalo ranks 6th for total offense, 12th for passing, 3rd for rushing, 4th for scoring, and 10th for fewest turnovers committed.
Buffalo ranks 15th for total defense, 1st vs. the pass, 30th vs. rush, 17th for fewest points allowed, and 29th for takeaways.
Chiefs at Bills Betting Trends
In the series between Kansas City and Buffalo, the Chiefs covered eight of the last 13 meetings. Six of the last eight games between the Chiefs and Bills went over the total.
The Chiefs covered the spread in four of their most recent five visits to Buffalo. Three of the last five games between the Chiefs and Bills at Buffalo went under the total.
The Chiefs have not shown improved betting value on the road. Kansas City is 3-7 against the spread in its last four away games. The Chiefs went over the total in six of their last ten road tilts.
Meanwhile, Buffalo has been a good long-term value at home. Buffalo got the cash in eight of its most recent 13 home games. Buffalo went over the total in 13 of their last 17 home games.
Chiefs at Bills Best Bets
Following a poor start, the Chiefs' resurgence has the casual sector back at the betting window. Most important of all, the Chiefs are keeping gamblers happy with a recent profit-taking run.
Still, the Chiefs are a very public team, and that popularity can affect their price and value.
On the other hand, Buffalo has been a drain on bankrolls. The Bills covered their first two games before encountering serious headwinds.
Certainly, the Bills will have a ferocious crowd out for blood and backing them. But the Chiefs will get a discount as the road team.
Naturally, this is a circle-the-wagons game for the Bills.
Although the Chiefs have Buffalo’s number, the Bills will get a good price. Last year, the Bills beat the Chiefs 30-21 at home in the regular season.
Main Pick: Buffalo Bills
Over/Under Pick: Under the Total
Player Prop Picks: Travis Kelce Under the Reception and Reception Yards Total
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