At the beginning of the 2025 future market action, the Penn State Nittany Lions and Ohio State Buckeyes were two of the most popular brands on the college football betting odds board.
Last year, Ohio State won the national championship while Penn State made the College Football Playoff Final Four. Hence, FOX was drooling for the November 1 clash of these rivals at the famed Horseshoe.
But what was expected to be an epic clash of superpowers is now a side attraction. Penn State fired head coach James Franklin on October 12 and is playing out the string.
On the other hand, heavily favored Ohio State looks ready for another natty.
Both teams are coming off bye weeks, strategically scheduled for this game.
Despite the Penn State problems, betting interest will be high for these Big Ten blue blood power brands. Additionally, FOX Big Noon games create heavy betting traffic.
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Penn State Nittany Lions at Ohio State Buckeyes Odds at Bookmaker
Ohio Stadium, AKA The Horseshoe, in Columbus, OH, is the venue for the matchup between the Ohio State Buckeyes and the Penn State Nittany Lions on Saturday, November 1, 2025. The kickoff time is at Noon ET, with television coverage on FOX.
Oddsmakers opened with Ohio State as a 20.5-point favorite and Penn State as a 20.5-point dog.
Ohio State is a -1800 moneyline favorite with Penn State as a +920 moneyline dog.
Ohio State and Penn State opened with a total of 44.5.
Penn State Nittany Lions
Last game, the Penn State Nittany Lions lost 25-24 against the Iowa Hawkeyes as 3-point road dogs. The game went over the total of 41.5. +
Penn State is 3-4 straight up, 1-6 against the spread, and 5-2 over/under the total.
Penn State ranks 101st for total offense, 112th for passing, 57th for rushing, 40th for scoring, and 47th for fewest turnovers committed.
Penn State ranks 17th for total defense, 6th vs. the pass, 89th vs the rush, 30th for fewest points allowed, and 65th for takeaways.
Ohio State Buckeyes
Last game, the Ohio State Buckeyes won 34-0 against the Wisconsin Badgers as 235-point road favorites. The game went under the total of 41.5.
Ohio State is 7-0 straight up, 6-0-1 against the spread, and 2-5 over/under the total.
Overall, Ohio State ranks 41st for total offense, 26th for passing, 72nd for rushing, 24th for scoring, and 9th for fewest turnovers committed.
Ohio State ranks 2nd for total defense, 5th vs. the pass, 8th vs rush, 1st for fewest points allowed, and 93rd for takeaways.
Penn State at Ohio State Betting Trends
Ohio State covered the spread in five of its most recent nine games with Penn State.
Only one of the last five games between Ohio State and Penn State went over the total.
Specifically, at Ohio Stadium, the Buckeyes have won four of their last seven games against Penn State.
The Nittany Lions and Buckeyes went under the total in ten of their most recent 12 meetings at The Shoe.
Overall, Penn State covered the spread in nine of its last 13 away games.
The Nittany Lions went over the total in 13 of their last 17 away games.
The Ohio State Buckeyes are 13-4-1 against the spread in their latest games at Ohio Stadium.
Ohio State went under the total in six of its last ten games at The Shoe.
Penn State at Ohio State Best Bets
Ohio State playing at The Shoe is one of the most iconic brands in sports betting. However, the Buckeyes are almost certain to be overpriced based on the intangibles and results in 2025.
Gamblers view the inept Penn State offense against the rock-ribbed Ohio State defense as a significant mismatch.
These days, Penn State is one of the most toxic brands in college football. Gamblers feel a sense of betrayal after the Nittany Lions were touted for the College Football Playoff.
It is hard to sell a Penn State team on the road against the defending national champions. Especially problematic is that Penn State has an interim coach and a backup starting quarterback.
The Ohio State defense should be able to control a struggling Penn State offense. Ohio State has the advantage on the field, with the coaches, and owns the trends.
Main Pick: Ohio State Buckeyes
Over/Under Pick: Under the Total
Player Prop Picks: Ethan Grunkemeyer Under the Passing Yards Total
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