San Diego Padres at San Francisco Giants MLB Lines

San Diego Padres at San Francisco Giants MLB Betting

NL West rivals collide Saturday afternoon when the San Diego Padres and San Francisco Giants lock horns in the second of a pivotal early-season three-game set. The Friars will be out to settle the score through the weekend after Gabe Kapler’s troops took two of three from San Diego at home back in early April. Sean Manaea absorbed a tough-luck loss in one of those games after getting outdueled by Logan Webb even after tossing six innings of 2 ER ball to go along with six strikeouts. His nemesis this time around will come in the form of a humbled Carlos Rodon who got absolutely shelled last time out in St. Louis where a nationally televised audience saw him get raked right from the outset. Rodon’s been at his best at home and in day games to date. As such, I expect him to be up to the task of matching zeroes with Manaea in what should amount to being one of the better pitcher duels of the weekend.

First pitch for the NL West showdown between the San Diego Padres and San Francisco Giants is scheduled for Saturday, May 21, 2022. Take it in live on FS1 at 4:05 p.m. ET from Oracle Park. Bet on MLB odds and player props at BookMaker.eu every day of the season.

MLB Betting Odds at BookMaker.eu

Odds Analysis

Though both San Diego and San Francisco are closer than they appear in LA’s rearview mirror, it’s the Dodgers that remain decided -255 chalk to take back NL West bragging rights. For reference sake, oddsmakers have installed the Padres +425 underdogs with the Giants right behind them at +430. In taking two of three from the Braves in Atlanta last weekend, San Diego entered the week 22-13 overall and up nearly $500 overall for MLB bettors. The pair of road wins moved them to 12-6 when away from Petco Park $414. As for San Francisco, it’s had a tough time mimicking last year’s effort that saw it rank out as the best overall wager in the game. While 20-14 overall, it’s only added $85 worth of baseball betting profit to its supporter’s bankrolls. Not nearly as dominant at home as a year ago, the Giants stand 11-7 as a host $16 to date.

Probable Pitchers

Sean Manaea L: So I touted the over in Manaea’s last start in Atlanta thinking he would have his hands full with a Braves offense that’s peppered left-handed pitching. Though Ronald Acuna Jr. sat that game out with a groin injury, it likely wouldn’t have mattered if he was in fact batting lead-off with the left-hander brilliant right from the first inning. When his day came to an end, the south paw tossed seven brilliant innings of six hit and 3 ER ball with a whopping 12 K! He shattered his strikeout prop along the way. Having already performed well against a Giants team that’s 5-1 and averages 5.7 runs per game against LHP, I’ll be banking on Manaea churning out a third straight quality start that keeps scoring to a minimum.

Carlos Rodon L: It looked like the Chicago White Sox made a grave mistake allowing Rodon to walk in the offseason. He started the season off on fire allowing a grand total of 11 hits and 3 ER while racking up a 38:8 K/BB ratio through four starts. Then after tossing two more quality efforts against the Dodgers and Rockies, the regression monster paid him an unforeseen visit in St. Louis where he was shelled for 10 hits 1 HR and 8 ER in his shortest stint of the year. As such, I can’t help but think he’ll be extra motivated to get back in the good graces of his teammates by tossing a gem. He gets the benefit of San Diego never seeing his stuff with this being his first-ever start against the franchise. Look for him to keep the Friars guessing!

Padres vs. Giants Prediction

Manaea has looked every part of being a bonafide ace his last three trips to the bump in conceding 18 hits, 9 ER and tallying a 26:6 K/BB ratio through nearly 20 combined innings of work. While his bloated 5.71 ERA in day games is concerning, he more than lived to tell about it in his last turn against a more powerful Braves attack. He’s allowed just 15 hits 1 HR and 8 ER through 26+ innings pitched under the sun. As for Rodon, I firmly expect him to rise to the occasion in this spot after getting his salad tossed last time out. He’s 2-0 with a 33:6 K/BB ratio and 2.12 ERA through three home starts to date, and was nasty in his lone day game start earlier in the season. Provided the series opener that pits Nick Martinez up against Jakob Junis doesn’t have both teams exhausting their best arms in the pen, I flat-out love the under for the first five innings as well as the full game for this showdown between stud left-handers!

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