College Football Week 10 Best Bets - Football Lines
Week 10 college football arrives with the national title chase tightening and multiple undefeated teams facing crucial November tests. Saturday college football beings in Columbus, where top-ranked Ohio State hosts Penn State in a Big Ten battle that carries major playoff implications as the Buckeyes look to maintain their perfect record against a Nittany Lions squad desperate to get back on track. With conference titles and the playoff picture at stake, the pressure ratchets up as the season enters its defining stretch.
The SEC remains the national focal point, as Vanderbilt—the surprise of the season—heads to Texas with both programs fighting for position atop the league and in the playoff race. The Commodores, riding historic momentum and a top-10 ranking, meet the Longhorns’ potent offense in a contest with major bowl and postseason stakes. Meanwhile, Georgia and Florida clash in Jacksonville, with both rivals aiming to solidify their standing after hard-fought Octobers.
A pivotal SEC showdown also unfolds in Knoxville, where Oklahoma looks to rebound from a damaging 34-26 home loss to Ole Miss. The Sooners visit Tennessee at Neyland Stadium with their playoff hopes in jeopardy and little margin for error. The Volunteers, coming off a road shootout win at Kentucky, seek a signature victory in front of their home crowd to bolster their own playoff resume.
Elsewhere, the ACC’s crowded title hunt features unbeaten Georgia Tech facing a road test at NC State, while Indiana’s perfect run is on the line at Maryland in the Big Ten. As conference races crystallize and every outcome affects the national postseason landscape, Week 10 stands as a key checkpoint—one where contenders must prove their staying power and hopefuls fight to keep their dreams alive.
Week 10 delivers the type of high-stakes college football that defines championship seasons, with prime television coverage across all major networks ensuring fans won't miss any of the action. From afternoon clashes to primetime spectacles, the weekend promises the kind of memorable moments that college football fans live for, with multiple games carrying both immediate and long-term consequences for the playoff chase.
College Football Betting Lines
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2025-2026 College Football Week 10 Schedule
Tuesday, October 28, 2025
8 p.m. | UTEP at Kennesaw State| ESPNU
8 p.m. | James Madison at Texas State | ESPN2
Wednesday, October 29, 2025
7:30 p.m. | Jacksonville State at Middle Tennessee | ESPN2
8 p.m. | Florida International at Missouri State | CBSSN
Thursday, October 30, 2025
7 p.m. | Norfolk State at Delaware State | ESPNU
7:30 p.m. | Marshall at Coastal Carolina | ESPN2
7:30 p.m. | Tulane at UTSA | ESPN
Friday, October 31, 2025
7 p.m. | Brown at Penn | ESPNU
7 p.m. | Memphis at Rice | ESPN2
7:30 p.m. | North Carolina at Syracuse | ESPN
8 p.m. | Sam Houston at Louisiana Tech | CBSSN
10:30 p.m. | Idaho at Northern Arizona | ESPN2
Saturday, November 1, 2025
12 p.m. | Penn State at Ohio State | FOX
12 p.m. | Vanderbilt at Texas | ABC
The Vanderbilt Commodores arrive in Austin riding high with a 7-1 mark and immense momentum after recent wins over tough opponents. Their offense, led by quarterback Diego Pavia, has been highly productive, averaging 38.4 points per game and their defense has held teams to under 19 points per outing. This week they face a chance for a signature victory in conference play at Texas, a team they narrowly lost to in their last meeting. The contest gives Vanderbilt an opportunity to build a bona fide résumé in the upper-tier of the conference.
Texas, meanwhile, comes into the game at 6-2 with some warts showing. While the Longhorns have won three straight and boast a strong home presence, their offense has been inconsistent and questions linger about quarterback Arch Manning and it could be Manning doesn’t even play this week, as he was in concussion protocol early in the week. Defensively, though, Texas remains stout, yielding just 14.6 points per game.
With home-field advantage at Darrell K Royal–Texas Memorial Stadium and needing a strong showing to stay in the playoff conversation, Texas must control Vanderbilt’s dynamic attack—particularly their passing game and explosive plays. The matchup could come down to which team forces turnovers and wins the trench battles.
12 p.m. | Rutgers at Illinois | NBC
12 p.m. | Duke at Clemson | ACCN
12 p.m. | Miami at SMU | ESPN
12 p.m. | UCF at Baylor | ESPNU
12 p.m. | UAB at UConn | CBSSN
12 p.m. | Army at Air Force | CBS/Paramount+
12 p.m. | Navy at North Texas | TBD
12 p.m. | Buffalo at Bowling Green | ESPN+
12 p.m. | Towson at North Carolina A&T
12 p.m. | New Haven at Sacred Heart | ESPN+
12 p.m. | Columbia at Yale | ESPN+
12 p.m. | Georgetown at Lehigh | ESPN+
12 p.m. | Long Island at Central Connecticut
12 p.m. | West Virginia at Houston | FS1
12 p.m. | Wagner at Saint Francis
1 p.m. | Monmouth at Bryant
1 p.m. | Stony Brook at Maine
1 p.m. | Gardner-Webb at Tennessee Tech | ESPN+
1 p.m. | Drake at Butler
1 p.m. | Davidson at Morehead State | ESPN+
1 p.m. | Valparaiso at Presbyterian | ESPN+
1 p.m. | Princeton at Cornell | ESPN+
1 p.m. | Lafayette at Holy Cross | ESPN+
1 p.m. | Robert Morris at Stonehill
1 p.m. | Merrimack at Colgate | ESPN+
1:30 p.m. | Samford at Wofford | ESPN+
2 p.m. | Montana State at Northern Colorado | ESPN+
2 p.m. | Charleston Southern at Southeast Missouri State | ESPN+
2 p.m. | Morgan State at South Carolina State | ESPN+
2 p.m. | North Dakota at South Dakota | ESPN+
2 p.m. | Mercer at Furman | ESPN+
2 p.m. | VMI at The Citadel | ESPN+
2 p.m. | Marist at St. Thomas-Minnesota
2 p.m. | Fordham at Richmond | ESPN+
2 p.m. | East Carolina at Temple | ESPN+
3 p.m. | Montana at Weber State | ESPN+
3 p.m. | UT Martin at Eastern Illinois | ESPN+
3 p.m. | Alabama A&M at Grambling
3 p.m. | Alabama State at Prairie View A&M
3 p.m. | Alcorn State at Texas Southern
3 p.m. | Southern at Arkansas-Pine Bluff
3 p.m. | Mississippi Valley State at Bethune-Cookman
3 p.m. | UNI at Illinois State | ESPN+
3 p.m. | Indiana State at South Dakota State | ESPN+
3 p.m. | Lamar at UIW | ESPN+
3 p.m. | Dartmouth at Harvard | ESPN+
3 p.m. | Louisville at Virginia Tech | The CW
3 p.m. | New Mexico at UNLV | TBD
3:30 p.m. | UAlbany at William & Mary
3:30 p.m. | NC Central at Howard | ESPN+
3:30 p.m. | Youngstown State at North Dakota State | ESPN+
3:30 p.m. | Indiana at Maryland | CBS
3:30 p.m. | Georgia vs. Florida | ABC
The Bulldogs come into this big rivalry matchup riding a strong 6-1 start and aiming to keep their trajectory toward an SEC title and playoff appearance. Their offense has found rhythm—in particular the running game which has averaged well over 190 rushing yards per matchup this season. On the other side, the Gators (3-4) are going through turbulence, having recently made coaching changes which always inject uncertainty for a single week.
The edge clearly belongs to Georgia, but the rivalry nature of this contest means Florida will be looking to spark something and flip the script. It’s also a critical moment for Georgia’s defense, which though talented has shown some vulnerability in recent games—particularly on third downs and in containing explosive plays.
Florida, meanwhile, has struggled with consistency, especially in turnover margin and finishing drives. That said, the environment of this matchup (neutral site in Jacksonville) and its emotional weight mean the Gators have the potential to at least make this a dogfight. If Georgia wants to avoid a trap, they’ll need to impose their physicality early and limit Florida’s opportunities for momentum shifts.
3:30 p.m. | Michigan State at Minnesota | BTN
3:30 p.m. | Pitt at Stanford | ACCN
3:30 p.m. | Delaware at Liberty | CBSSN
3:30 p.m. | New Mexico State at Western Kentucky | ESPN+
3:30 p.m. | Fresno State at Boise State | FS1
3:30 p.m. | Old Dominion at UL Monroe | ESPN+
3:30 p.m. | Louisiana at South Alabama | ESPN+
3:30 p.m. | Notre Dame at Boston College | ESPN
3:30 p.m. | Texas Tech at Kansas State | FOX
3:45 p.m. | Virginia at California | ESPN 2
4 p.m. | Sacramento State at Eastern Washington | ESPN+
4 p.m. | Idaho State at UC Davis | ESPN+
4 p.m. | Tarleton State at Abilene Christian | ESPN+
4 p.m. | North Alabama at Utah Tech | ESPN+
4 p.m. | Houston Christian at Nicholls | ESPN+
4 p.m. | Western Carolina at Chattanooga | ESPN+
4 p.m. | Dayton at San Diego | ESPN+
4 p.m. | Arizona at Colorado | FS1
4 p.m. | Mississippi State at Arkansas | SECN
4 p.m. | Oklahoma State at Kansas | ESPN+
4 p.m. | Central Michigan at Western Michigan | ESPNU
4:30 p.m. | Lindenwood at Tennessee State | ESPN+
5 p.m. | Portland State at Cal Poly | ESPN+
5 p.m. | Eastern Kentucky at Central Arkansas
5 p.m. | Southern Illinois at Murray State | ESPN+
7 p.m. | Jackson State at Florida A&M | ESPN+
7 p.m. | East Texas A&M at SE Louisiana | ESPN+
7 p.m. | Northwestern State at McNeese | ESPN+
7 p.m. | UT Rio Grande Valley at Stephen F. Austin | ESPN+
7 p.m. | Purdue at Michigan | BTN
7 p.m. | Wyoming at San Diego State | CBSSN
7 p.m. | South Carolina at Ole Miss | ESPN
7:30 p.m. | Georgia Tech at NC State | ESPN2
7:30 p.m. | Oklahoma at Tennessee | ABC
Tennessee comes into this one riding a potent offense that ranks among the country’s best: the Volunteers average about 510 yards per game and 45.6 points per outing, both top-5 national marks. Defensively, however, they’ve had issues: they rank near the bottom nationally in passing yards allowed and give up around 30.9 points per game. In short, Tennessee must score freely and play the complementary half (defense/special teams) to keep control.
Oklahoma, by contrast, has leaned on a stifling defense which ranks among the elite: they allow only 240 yards per game, are top-10 in both pass and rush defense, and surrender just 12.5 points per game. Offensively, though, the Sooners have been subpar, averaging just 376 yards and 28.4 points per game. They’ll need those defenses to carry more weight than usual if they want to pull off the win on the road. The matchup may well come down to whether Oklahoma’s defense can slow Tennessee’s high-octane offense AND whether the Sooners can find enough offense to avoid a blowout.
7:30 p.m. | Kentucky at Auburn | SECN
7:30 p.m. | Southern Cal at Nebraska | NBC
7:30 p.m. | Washington State at Oregon State | CBS
7:30 p.m. | Wake Forest at Florida State | ACCN
8 p.m. | Arkansas State at Troy | ESPNU
8:30 p.m. | Austin Peay at Southern Utah | ESPN+
10:15 p.m. | Cincinnati at Utah | ESPN
10:30 p.m. | Hawai'i at San Jose State | CBSSN
2025-2026 College Football Schedule
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